Virax Biolabs Group Limited (NASDAQ: VRAX) ("Virax" or the "Company"), an innovative biotechnology company focused on the detection of immune responses and diagnosis of viral diseases, today announced ...

▎药明康德内容团队编辑  结直肠癌（CRC）是全球第三大常见癌症，其死亡率不断上升。美国FDA已批准使用免疫检查点抑制剂（ICI）治疗CRC，包括PD-1抑制剂，然而超过85%具有pMMR/MSS特征的患者几乎无法从中受益。癌细胞具有高度的代谢状态， ...

在免疫学领域，CD8+T 细胞在抵抗病毒感染、癌症以及自身免疫疾病中扮演着至关重要的角色。 因此，准确预测 T 细胞受体（TCR，T cell receptor）与主要组织相容性复合物（MHC，Major Histocompatibility ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

老规矩，奇点糕开头先问大家一个问题：在激活CD8+T细胞抗肿瘤免疫应答时，有哪些细胞会起到重要作用呢？回答树突状细胞（DCs）是肯定没问题的，它们的抗原呈递功能确实广为人知，但各位要记住了，从今天开始DCs可就不是问题唯一的“正解”了。因为在今天的《 ...

已经广泛证明，通过特异性抗体-抗原复合物将抗原靶向DEC-205，可以有效地摄取和呈递MHC I和MHC II复合物上的抗原，从而分别激活抗原特异性CD8+和CD4+T细胞 ... in Experimental Colitis in Mice" Eur J Microbiol Immunol (Bp) 6(1):1-8. Flow Cytometry Mitsuoka N, Iwagaki H, ...

1 Department of Computational Biology and Medical Sciences ... Major histocompatibility complex class II (MHC-II) is essential for immune surveillance within the TME. While MHC-II genes are typically ...

研究发现，能表达名为UL18的特异性人类巨细胞病毒基因的恒河猴巨细胞病毒仅能诱发标准反应，因为UL18能与T细胞上的抑制性受体相互作用并阻断其 ...

Recipient T cells recognize donor antigens via two distinct pathways: the direct pathway (intact donor MHC molecules displayed on donor antigen-presenting cells [APCs]) and the indirect pathway ...