Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8 + T cells. Like other cell ...

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

Figure 1. Mechanisms of antigen presentation via major histocompatibility complex class I (MHC-I) and class II (MHC-II). The left panel illustrates MHC-I presentation, where intracellular proteins are ...

Houston ISD’s Yates High School — along with four other campuses in the district — will formally end their International Baccalaureate programs in the 2025-2026 academic year, according to ...

2025年肿瘤免疫治疗市场预计突破千亿美元规模，但晚期实体瘤患者中仍有超60%对PD-1单药治疗无响应。中山大学团队在《血液学与肿瘤学杂志》发布的重磅临床研究，揭示了LAG-3/PD-1双靶点联合疗法在鼻咽癌等实体瘤中的突破性进展，这项涉及全国多中心的Ib/II期试验不仅带来11.3%的3级以上不良反应率、33.3%鼻咽癌客观缓解率的亮眼数据，更可能重塑实体瘤免疫治疗格局。

个性化癌症治疗疫苗在几项正在进行的临床试验中取得了令人鼓舞的结果，可能代表了一种前景广阔的癌症免疫疗法策略。新表位（Neoepitopes）是由肿瘤特异性突变形成的新抗原上的T细胞受体（TCR）识别的免疫原部分，是开发癌症疫苗的关键。它们的特异性源于其肿瘤专属性，降低了对正常组织产生免疫反应的可能性，因此，可以克服传统的免疫耐受障碍。这一独特性使新表位成为T细胞最 “有利 ...

Objectives This study aimed to estimate the prevalence of, and factors associated with, accessing maternal healthcare services (MHC) by Indigenous women in the Chittagong Hill Tracts (CHT), Bangladesh ...

Bone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells (MSCs) — are the common predecessors of cells of the mesenchymal lineage, such as bone, cartilage and fat ...

These findings suggest that the major histocompatibility complex (MHC) association with psoriasis lies close to the HLA-C region and the association with the articular manifestations lies in or close ...

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...

George Coukos, MD, PhD, Department of Oncology, University Hospital of Lausanne, Rue du Bugnon 46, Lausanne 1011, Switzerland; e-mail: [email protected]. If you have the appropriate software installed ...