The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inhibits the mitochondrial complex I of the respiratory chain. This results in ATP and ion homeostasis disturbances, which lead to selective ...
One of the representative systems proposed to be responsible for the MOMP is the mitochondrial permeability transition pore (MPTP). Although the molecular composition of the MPTP is not clearly ...
BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.
环RNA（circular RNA，circRNA）是一大类共价闭环的单链 RNA 分子。近年来的研究表明，circRNA 具有重要的调控功能并在多种疾病的发生发展中起着重要作用。目前已知动物细胞中的 ...
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好书推荐！《动物行为实验手册》电子版pdf，网盘发货！动物行为学实验是神经科学研究领域的重要组成部分，主要侧重于科学客观地评价各种条件下的动物行为。动物行为学实验种类繁多，研究不同的疾病模型时，研究人员需根据关注的具体行为选择合适的研究手段。《动物行 ...
研究表明，在研基因疗法AB-1005（曾称AAV2-GDNF）的安全性良好，临床结果持续呈积极趋势，没有与产品相关的严重不良反应事件； ...
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Purpose: The pharmacology, pharmacokinetics, clinical efficacy, and safety of rasagiline are reviewed. Summary: Rasagiline is a novel, investigational propargylamine that irreversibly and ...
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