Abnormal macrophage behaviour is also seen in fibrotic ... tissue regenerating or immune-suppressive.” Likely disease targets will be inflammatory bowel disease, uric formation, and lupus.

We highlight current biotherapy methods for restoring the function of macrophages. Finally, important molecular targets and novel macrophage-based treatment for chronic wounds are proposed from the ...

A discovery offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists have pinpointed proteins in ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction ...

A research team of Peking University (PKU) conducts research of tumor cachexia in a laboratory at PKU in Beijing, capital of ...

The development of ALI/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating the inflammatory response in ALI/ARDS. In this paper, we review the ...

Conclusions Synovial macrophage M1 polarisation exacerbates experimental CIOA partially through Rspo2. M1 macrophages and Rspo2 are potential therapeutic targets for OA treatment. Contributors HZ and ...

A discovery at Duke-NUS Medical School offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists ...

Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.