The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

Cancer metabolism refers to the alterations in cellular ... Large-scale profiling of drug-induced metabolic changes have potential for improving drug development but remain challenging.

Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for ...

Natural ways to boost metabolism can be fun and easy. Simple things like eating more protein, high-intensity interval training, lifting weights, avoiding skipping meals, drinking the right things, ...

Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

Recently, emerging investigations revealed that metabolism profiles control macrophage phenotypes and functions, and in turn, polarization can trigger metabolic shifts in macrophages. Those findings ...

Drug addiction is a condition in which there is uncontrolled use of a substance with a harmful outcome. Drugs overstimulate the brain’s reward circuit, producing pleasure or euphoria. With repeated ...

It is now widely recognised that host–microbiome interactions play a major role in the control of energy metabolism and ...

Most mutations that decreased antibiotic susceptibility were related to specific metabolic pathways. A MIC-increase to ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands 4 University of Groningen and University Medical Center Groningen, Department of Medical Microbiology, ...

Drug screening is the process by which potential drugs are identified and optimized before selection of a candidate drug to progress to clinical trials. It can involve screening large libraries of ...