Six Sigma is a quality management methodology used to help businesses improve current processes, products, or services by discovering and eliminating defects. The goal is to streamline quality ...

Learn from anywhere on your own schedule with our 100% online format. Purdue University delivers a best-in-class online Lean Six Sigma (LSS) certificate program for learners with a range of career ...

The traditional full line pharmacy wholesale distribution business, retail and private label products. Also has national Presence in the hospital pharmacy distribution market, and through its ...

MG132 (Millipore) was stored at −20°C as a stock solution at 5 mM in DMSO. Cells were treated with MG132 (5 μM) for 2 h. For cycloheximide (CHX, Sigma-Aldrich) chase analysis, 100 μg/ml CHX was used ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The SCF (SKP1/CUL1/F-box protein) ubiquitin ...

Monoclonal anti-FLAG antibody and anti-β-actin were obtained from Sigma (St. Louis, United States ... Ferrostatin-1 (Fer-1), Erastin, and carbobenzoxy-Leu-Leu-leucinal (MG132) were all purchased from ...

Tumour necrosis factor-α (TNF-α) and zVAD were obtained from R&D Systems (Minneapolis, USA). Cycloheximide, Pepstatin A and MG132 were purchased from Calbiochem (San Diego, USA). Chloroquine ...

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.