Using α-syn fibril-induced PD model, researchers aimed to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain by the wireless DBS nanosystem. After stereotactic ...

Using an α-syn fibril-induced PD model, the researchers attempted to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain through use of the wireless DBS nanosystem.

The pathological hallmark of PD is the abnormal aggregation of α-synuclein (α-syn) into insoluble fibrils and Lewy bodies, which causes the degeneration and death of dopaminergic neurons in the ...

The neuropathological hallmarks of PD include loss of dopaminergic neurons in the midbrain substantia nigra pars compacta (SNpc) and accumulation of Lewy bodies (LBs) containing α-synuclein.

There are three dopaminergic pathways, namely the striatonigral pathway (substantia nigra to caudate and putamen), the mesolimbic pathway (ventral tegmental area of midbrain to limbic areas of ...

Parkinson’s disease is a progressive neurodegenerative disease that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment ...

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation and is believed to consist of a short-lived phasic and continuous tonic component. Here, we build a ...

Recently proposed staging systems of PD have suggested that degeneration may occur initially in areas outside the substantia nigra, suggesting that non-motor manifestations may be markers of ...

Parkinson's disease (PD), a common neurodegenerative disorder, is characterised by a selective loss of dopaminergic (DA) neurons from the pars compacta of the substantia nigra, and the formation of ...

A Colorado Springs family hopes to win what they believe would be a landmark legal verdict by proving to jurors next month that mold exposure in a rented apartment caused Parkinson's disease in a ...