Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.
Feb. 26, 2025 — Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice ...
Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools ...
在研究结论和讨论部分,我们可以看到这项研究有着重要意义。线粒体能量代谢的重编程在胃癌发展和癌细胞干性维持中起着关键作用,而目前的治疗方法,如手术和化疗,存在肿瘤复发和耐药的问题,所以需要新的针对线粒体的治疗策略。本次研究发现,人胃上皮线粒体移植可以调节胃癌细胞的代谢,抑制癌症干性,促进凋亡,降低化疗耐药性,在体内实验中也显著抑制了肿瘤生长。这不仅揭示了胃上皮线粒体移植在胃癌治疗中的潜在作用,还为胃 ...
这项研究成果于2月23日发表在《Stem Cell Research & Therapy》期刊上 ... 通过 DHE 染色评估细胞内氧化应激,用 MitoSOX 和 Seahorse 生物分析仪评估线粒体代谢功能。结果发现,移植 GES-1 上皮线粒体后,细胞内和线粒体内的 ROS 水平都升高了。而且,移植的胃上皮线粒 ...