The current CF drug development landscape has expanded to include therapies that enhance CFTR function by either restoring wild-type CFTR protein expression or increasing (modulating) the function of ...

A higher rescue of CFTR function, up to 25%–35% of the normal CFTR activity, with no evidence of negative effects upon chronic ... The G85E mutation is characterized by a severe folding defect that ...

Studying patient-derived tissues or organoids with GUCY2C mutations might contribute to the understanding of cGMP-mediated stimulation of chloride secretion by cystic fibrosis transmembrane ...

The neuronal aggregates that are observed in HD cases are not only composed of mutant huntingtin but also of other proteins, including normal huntingtin 11. In this regard, it is possible that ...

Fibrosis is the outcome of any abnormal tissue repair process that results in normal tissue replacement with scar tissue ... SUMOylation of PML, TGFβRI, Smad4, Twist2, FXR, Sirt3, STAT1, HIF-1α, and ...

If you're a fan of the half-shell heroes, you can lose yourself in dozens of digital comic books starring the iconic brothers with Humble's new Teenage Mutant Ninja Turtles Ultimate Collection ...

A normal heart rate for a fetus can range from 110 to 160 beats per minute (BPM). Very early in pregnancy, it is typically around 110 BPM. Fetal heart rate may speed up to 140 to 170 BPM around the ...

You’ve reached your account maximum for followed topics. A Call of Duty: Black Ops 6 player stumbles across a major issue with one of the game's weapon blueprints from the Season 1 Battle Pass ...

When you brush or wash your hair, most of the hairs that you see are part of this normal process. Stress and certain health conditions may cause increased shedding. Hair with plenty of volume ...

Lymphocytes are a type of white blood cell. They play a key role in your immune system by helping your body fight infection and disease. Normal lymphocyte counts are generally between 1,000 and 4,800 ...