The neuronal aggregates that are observed in HD cases are not only composed of mutant huntingtin but also of other proteins, including normal huntingtin 11. In this regard, it is possible that ...

Hospital, Freiburg, Germany) reported that expression of mutant CFTR induces NF-κB expression ... homozygous eIF2α-mutant mice is apparently normal, but homozygous eIF2α-mutant cells are ...

Join Peter Grootenhuis of Vertex Pharmaceuticals as he delivers a brief overview of the drug discovery approaches and challenges to identify small molecules CFTR modulators. These compounds improve ...