Systemic lupus erythematosus (SLE) is an autoimmune disease that sometimes involves the central nervous system in a condition known as neuropsychiatric SLE (NPSLE). Research in mice has shown that ...

One of the organs affected by this loss of self-tolerance is the brain. The brain disease that results from SLE is called neuropsychiatric lupus, or NPSLE. NPSLE affects up to 70% of patients with SLE ...

From a clinical point of view, NPSLE events can manifest as acute or recurrent, silent or overt and might be unnoticed or catastrophic. As examples, ischemic stroke might be asymptomatic or lead ...