Led first by the discovery of osteoprotegerin (OPG), a naturally occurring protein with potent osteoclastogenesis inhibitory activity, rapid progress was made to the isolation of RANKL ...

OPG and RANKL Are Regulated by Systemic Hormones, Growth Factors, and Cytokines Cite this: Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption ...

RANKL, receptor activator of nuclear factor factor-kappa B ligand; RANK, receptor activator of nuclear factor-kappa B; OPG, osteoprotegerin. When S1P binds with S1PR1, it forms a complex that governs ...

Chronic inflammation and bone loss are closely linked pathophysiologic events. The most typical example of inflammatory bone loss is seen in patients with rheumatoid arthritis who develop systemic ...

Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies and ultimately leads to right heart failure as the predominant cause of morbidity and mortality. In patients, ...

Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical ...

Comparative analysis of both cohorts combined, yielded 212 differentially expressed probe sets. The top five differentially expressed genes in a combined analysis of both cohorts were osteoprotegerin, ...

1 Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China 2 Department of Medicine, Princess Margaret Hospital, Hong Kong, SAR China 3 Department of Clinical Pathology, Tuen Mun Hospital, Hong ...