除了细胞分裂次数达到极限外，物理损伤、营养不良或紫外线引起的DNA损伤等因素也会导致细胞衰老。研究人员最初认为，发生细胞衰老是为了防止受损细胞无限制地复制并引发癌症。在某种程度上可能的确如此，但如果细胞不是单纯地死掉，像可控的凋亡程序 ...

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic stresses, are our bodies’ greatest weapons to battle against cancer onset and development. Consequently, factors that ...

原文作者：Carissa Wong本篇《自然》长文共4105字，预计阅读时间13分钟，时间不够建议可以先“浮窗”或者收藏哦。科学家们正在致力于使用新型分子、改造免疫细胞和基因疗法来杀死衰老细胞，治疗年龄相关的疾病。插图：Paweł ...

Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss hormonal therapy updates and different ways to target and ...

The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...

CEBU, Philippines — After nearly two decades of planning and deliberation, the P16.9 billion New Cebu International Container Port (NCICP) in Barangay Tayud, Consolacion, Cebu officially broke ...

腰痛已成为全球性的重大健康问题，给社会带来了沉重的经济负担，并且随着人口老龄化的加剧，这一问题愈发严重。众多研究表明，腰痛与椎间盘退变密切相关。椎间盘退变过程中，髓核细胞（nucleus pulposus cells，NPCs）和细胞外基质（extracellular matrix，ECM）会逐渐流失。细胞外基质主要由胶原纤维和蛋白聚糖（如聚集蛋白聚糖）组成，主要由髓核细胞产生并维持，其中 ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...