The mRNA expression levels of FOXO1 and p62 were assessed using real-time quantitative PCR, and the activation level of autophagy was evaluated at the mRNA level. p62 is a crucial autophagy substrate, ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

CCT2 mediates aggrephagy through a unique mechanism that is distinct from canonical autophagy receptors such as p62, NBR1, and TAX1BP1 (Ma et al., 2022a). These receptors typically recognize ...

A mouse xenograft model of DLBCL tumors was used to characterize the role of TNFAIP3 expression tumor growth. Tumors induced from cells with higher levels of TNFAIP3 had a lower volume compared with ...

By Dr. Liji Thomas, MD Study finds that consuming more caffeine may improve heart health. Study: Caffeine improves systemic ...

Autophagy activity was evaluated via Western blot of p62 and LC3 II. Macrophage infiltration and apoptosis was assessed by immunofluorescence microscopy, while Masson's Trichrome staining detected ...

A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy.

Autophagy is a process by which cells break down and recycle their own components to maintain homeostasis. The research team scrutinized the autophagy process in astrocytes and discovered that ...