Protein complex in bacterial cell membrane acts like a rotary motor to recruit DNA-degrading enzymes to defend against phage infection.

Students isolate novel bacteriophage from the environment and characterize those phage using current research techniques including electron microscopy and DNA analysis. The genomic DNA from some of ...

Day1: Phage Discovery & Genomics allows you to explore the hidden world that exists all around you. Isolate, characterize and name your newly discovered phage. Sequence the DNA of your phage and ...

Jumbo phages utilize a complex protein import system, with Imp1 as a key gatekeeper, to transport proteins into their ...

In this two-semester program, you’ll gather specimens and isolate a unique bacterial virus, called a “phage.” You will use research methods to characterize and analyze your phage, and then catalog ...

Meet the jumbo phage. Scientists believe they’ve cracked the code on how its ‘secret handshakes’ act as a shield against the ...

John McCafferty, Cambridge Institute of Therapeutic Immunology and Infectious Disease Additionally, because the protein would be bound to the bacteriophage with the inserted DNA, the product and ...

They looked closely at the endonuclease, an enzyme that serves as a DNA cutting tool. The endonuclease from one phage's ...

Scientists insert variable DNA sequences coding for their proteins of interest into plasmids that carry a phage coat protein gene, an antibiotic resistance gene, and a packaging signal. Then they ...

Strep throat, something we've all had at some point in our lives, is caused by the bacteria Streptococcus pyogenes. Infection ...

In 2020, Bondy-Denomy led a study showing that the protein shield protects the phage's DNA from attacks by the bacteria's defenses. He and Claire Kokontis, BS, a graduate student, suspected this ...