With the rapid development of antibiotics in the 1930s, phage therapy – using viruses known as bacteriophages or phages to tackle bacterial infections – fell into oblivion.
An approach from biotechnology firm Phase Genomics in Seattle, Washington, is also allowing scientists to catch phage DNA in the act of infecting bacteria cells. The firm uses chemical ...
These anti-phage defense systems are carefully controlled ... hundreds of these enzymes—although a few are known to target DNA or RNA, all but a handful target proteins. This is the first ...
Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation).