According to the IUIS, primary immunodeficiencies are classified in 8 groups: combined immunodeficiencies; predominantly antibody deficiencies; diseases of immune dysregulation; congenital defects of ...

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and ...

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and ...

The 40 monogenic defects with IBD-like pathology selected in this review can be grouped into defects in intestinal epithelial barrier and stress response, immunodeficiencies affecting granulocyte and ...

Researchers identified new drivers in neuron remodeling, shedding light on how the brain refines neural circuitry during ...

Multiple sclerosis (MS) is one of the major neurodegenerative diseases. Many drugs are available for MS therapy, but these treatments often do not effectively halt disease progression. Thus, the ...

Figure. Pathways for clearance of microvesicles from the circulation. In normal conditions, the lactadherin pathway mediates clearance of microvesicles. Macrophages in the spleen secrete lactadherin, ...