Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant ... and related multi-omic strategies lend themselves well to phenotypes with polygenic modes of ...

They induce various adverse drug reactions depending on their mechanisms of action: metabolic effects, such as weight gain and alterations of glucose and lipid metabolism; hyperprolactinemia and ...

No serious side effects or discomfort observed Final safety and absorption data expected in March 2025 SARASOTA, FL, Feb. 11, ...

Ficerafusp alfa enters phase 2/3 trial for recurrent/metastatic head and neck cancer, evaluating its combination with Keytruda for first-line treatment.

The importance of pharmacokinetic (PK) and pharmacodynamic (PD ... PK studies absorption, distribution, metabolism and excretion of drugs. PK studies guide the determination of a drug’s optimal route ...

In summary, the metabolism of the CNFD drug candidate was characterized for the first time. The data established in the kinetic study were used to predict important pharmacokinetic parameters, ...

Purpose: The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed. Summary: Polycyclic aromatic ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

ALDERLEY PARK, Cheshire - Infex Therapeutics Holdings plc, a UK-based anti-infectives specialist, in partnership with Justus-Liebig-University Giessen (JLU) in Germany, has been awarded a £1 million ...

Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes remains crucial in pharmaceutical drug discovery and development. Both direct and time-dependent inhibition of drug ...