NRF1 plays a critical role in the formation of p62-positive puncta, facilitating the aggregation of p62 proteins after proteasome inhibition. This process is crucial for the efficient clearance of ...

The basic scheme here is known as confocal laser scanning fluorescence microscopy, where a laser at one wavelength excites fluorescent tags bound to structures in a sample. Light emitted by the ...

Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell’s recycling process for obsolete and misshapen proteins—known as proteasomes ...

Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a ...

The final 20S proteasome product looks less like cartoon mechanized lions forming a microscopic Voltron and more like a humble barrel, albeit just as destructive to proteins targeted for recycling ...

The Olympus FluoView FV1000 Confocal Microscope is a laser scanning biological microscope. It minimizes specimen damage during high-speed imaging of living organisms. It accurately captures a full ...

The Cell Imaging Center houses two types of confocal microscopes: the Olympus FV1000 and the Zeiss LSM700. In confocal microscopy, laser light is focused into a very small spot and is scanned across ...

The Confocal Microscopy and Image Analysis Core provides instrumentation and expertise to support the acquisition, processing and analysis of both fluorescence and bright-field micrographs captured ...

A confocal microscope is a kind of fluorescent microscope used to obtain high-quality 2D and 3D images. The device is most commonly used to view cells and cell structures, but can be used to ...

T he typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle ...

Welcome to the Confocal Microscopy Lab at RIT. This lab provides faculty and students with a multidisciplinary imaging research and training facility centered around confocal microscopy. The ...