Our data indicate that the fundamental regulators of transcription and chromatin remodeling, rather than interaction with NL proteins, play a major role in transcription regulation within LADs. Lamina ...
Hsp70 solubilizes aggregates and aids protein refolding through substrate binding and release cycles regulated by co-chaperones: J-domain proteins (JDPs) and Nucleotide Exchange Factors (NEFs). Here, ...
The cargo-binding domain of KIF5 motors binds to the adaptor glutamate receptor-interacting protein 1 (GRIP1), which binds to the GluR2 subunit of AMPAR 63. The dendritic transport of GluR2 by ...
Considering that many apical membrane proteins have very short or non-existent cytoplasmic domains—meaning that most of their bulk resides within or outside of the plasma membrane and not inside ...