High levels correlated with mild symptoms; sicker patients’ antibodies sported fewer sialic acid links. Wang and her colleagues explored further, using bioengineered mice whose cells expressed human ...
Sialic acid (blue links) at the end of sugar chains attached to antibodies (red) induce the antibodies to bind to receptors (light blue) that promote an anti-inflammatory response in alveolar ...
Wang and her colleagues explored further, using bioengineered mice whose cells expressed human receptors for antibodies. "We gave the mice human antibodies differing only in their sialic acid ...
researchers replaced protein-receptor ACE2 with saccharide-receptor sialic acid (SA) and again found potent clearance of influenza A by the lysosomal trap in cell, mouse, and human lung organoid ...