The overexpression of Bcl-2 by gene transfer abrogated both ROS generation and apoptosis induced by edelfosine in leukemic cells. Changes in the relative mitochondrial membrane potential were ...

BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.

triggering ROS production, mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese ...

To specifically study the location-dependent effect of hydrogen peroxide release, they used D-amino acid oxidase (DAAO), which produces this ROS upon addition of D-alanine. 2 The team fused DAAO to ...

This has been done in order to follow mitochondrial actions due to loss of their membrane potential, probable opening of the permeability transition pore and release of proapoptotic signals (e.g.