This valuable study investigates the signaling pathways regulating retina regeneration. Solid evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following retinal ...

Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression.

Lipids are hydrophobic or amphiphilic small molecules that include sterols, waxes, fatty acids and phospholipids, and are insoluble in water and soluble in organic solvent. Biological lipids are ...

Sphingosine is a membrane component in all cells and constitutes 25% of the lipid in the myelin sheath. Sphingosine is phosphorylated by ubiquitously expressed sphingosine kinases. S1P regulates ...

US-based Filipino chemist Dr. Webster L. Santos has discovered and patented a groundbreaking new class of small-molecule drugs for treating acute kidney injury (AKI) and autoimmune diseases. In an ...

A team of researchers led by Professor Ningling Kang, PhD, at The Hormel Institute, University of Minnesota, has published an ...

These “find-me” signals encompass chemokines such as CX3C-chemokine ligand 1 (CX3CL1) also known as fractalkine, lipids such as sphingosine 1-phosphate (S1P) and lysophosphatidylcholine (LPC), and ...

That pathway involves a chain reaction of events from a lipid called sphingosine-1-phosphate (S1P), protein kinase M zeta (PKMζ), and a protein called vasodilator-stimulated phosphoprotein (VASP ...

This study investigates the molecular mechanisms underlying chronic pain-related memory impairment by focusing on S1P/S1PR1 signaling in the dentate gyrus (DG) of the hippocampus. Through behavioral ...

“High fibre foods include beans, vegetables, fruits, nuts, seeds and whole grains.” Soluble fibre, the main type of fibre found in plant foods, can bind to cholesterol in the intestine and remove it ...

Among the 122 different metabolites found, there were 23 amino acids and 21 fatty acids. Most of the metabolites were involved with ammonia recycling; amino acid metabolism; arachidonic acid ...