the nuclear import and export of the Kinesin-8 heterodimer Klp5–Klp6 is controlled to ensure localization to cytoplasmic microtubules in interphase and to the nuclear mitotic spindle during ...

1 Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China 2 Synthetic Biology Research Center, Shenzhen University, ...

Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle dynamics. These functions require binding partners such as CEP192 and TPX2, which modulate both kinase ...

In differentiated cells, non-centrosomal (nc) MTOCs can reorganize microtubules, with cellular localization varying between cell types ... Our results indicate that LMNB2 is essential for mitotic ...

To pull it off, these microscopic hollow tube structures, called “microtubules,” don’t rely on our everyday flavor of classical physics. Instead, experts believe, microtubules perform ...

The classic view posited elongation occurs through the deposition of cytoskeletal elements in the growth cone at the tip of a stationary array of microtubules. Yet, recent studies reveal axonal ...

The team mixes bundles of microtubules—biopolymers crucial for ... from cell alignment in tissues to the mitotic spindle organization during cell division. "Beyond confirming a theory, this ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polyglutamylation is a reversible ...

The protein tubulin — what centrosomes and microtubules are primarily comprised of — is stained magenta while the protein PPP2R3C, which localizes at centrosomes, is stained green.

C3-transferase was applied to the embryo during the 4-8 cell stage division, before fixation and imaging. Colcemid treatment has been previously used to depolymerize microtubules in the embryo ...