Among these genes, B0035.1 (bugz-1) encodes ortholog of mammalian C2H2 zinc-finger protein BuGZ/ZNF207, which is a spindle assembly checkpoint protein essential for mitosis in human cells. Combining ...

To understand how the two functionally redundant Kinesin-14A motors contributed to the spindle assembly, we had ATK1-GFP and ATK5-GFP fusion proteins expressed in their corresponding null mutants and ...

Imaging the molecules in a dividing cell's "spindle," a protein structure that extends from one side of the cell to the other ...

A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized ...

The hybrid microscope can be useful for studying proteins, as they change their 3D orientation in response to their ...

Researchers from Wuyi University presented the discovery and preclinical characterization of kinesin spindle protein (KSP) degraders developed using proteolysis-targeting chimera (PROTAC) technology.

The microscope's ability to record 3D protein orientation changes is crucial for understanding how proteins interact with ...

Two heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish ...

Two heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish feats that neither could have done on its own.

The microscope uses two technologies to capture molecules' 3D position and orientation, helping scientists study biological ...