Synthetic biologists from Yale were able to re-write the genetic code of an organism — a novel genomically recoded organism (GRO) with one stop codon — using a cellular platform that they developed ...

Yale researchers have created "Ochre," a genomically recoded organism that enables the production of synthetic proteins with novel properties, paving the way for groundbreaking applications in ...

How does DNA determine an organism’s characteristics? A process called translation decodes RNA created during transcription, and uses it to create proteins that perform specific cellular functions.

Consequently, the mutant protein is entirely different due to the deletion of the fourth nucleotide, and it is also shorter due to the appearance of a premature stop codon. This mutant protein ...

Each gene has usually two versions within the library: with and without stop codon. If you plan to make use of a vector containing C-terminal tags, select the version without stop codon. The MGC ...

More information: Michael W. Grome et al, Engineering a genomically recoded organism with one stop codon, Nature (2025). DOI: 10.1038/s41586-024-08501-x Provided by Yale University ...