This work can be of interest to a broad community of structural biophysicists, computational biologists, chemists, and biochemists. xCas9 is an evolved variant of the CRISPR-Cas9 genome editing system ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...