eLife1 个月
AXONAL distribution of mitochondria maintains neuronal autophagy during aging via eIF2β
In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...
Frontiers7 个月
Causal gene identification using mitochondria-associated genome-wide mendelian ...
Background: Mitochondrial dysfunction is one of the important patho-mechanisms in the development of atrial fibrillation (AF) with underidentified genetic pathophysiology. Methods: Summarized data of ...
ahajournals.org7 个月
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice
We conducted empagliflozin dose-ranging studies in C57BL/6NJ male mice to approximate efficacious doses used in human clinical trials. 4 When admixed to a laboratory rodent diet (LabDiet, #5001), a ...