CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

Tumor-antigen-specific CD8 + T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8 + T cells that are associated with a poor clinical ...

A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed that aging specifically impairs the generation of CD8+ tissue resident memory ...

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging ...

In a study published in Nature Aging on Nov. 26, a research team from the Shanghai Institute of Nutrition and Health (SINH) ...

Researchers have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the disease and are more likely to relapse ...

ALL, certain drugs work for some patients who relapse, but these drugs are not effective for all patients who relapse.

Copyright: © 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Chimeric antigen receptor ...

Called Vance, the global, multinational, randomised phase three trial, led by Singapore clinician-scientist Toh Han Chong, is the largest completed trial on T-cell therapy on any solid tumour.

How the cell decides between these competing demands hasn't been clear ... result is an almost perfect division of labor, with one subpopulation outfitted with the machinery for making ATP ...