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华人学者工程化噬菌体实现口服给药,依托肠道菌群动态释放药物 ...
相较于传统口服生物药,噬菌体递送系统具有独特优势。它能够 直接在肠道局部释放蛋白 ,避免系统性分布导致的脱靶效应。噬菌体与宿主菌形成动态平衡,可按需释放蛋白,减少频繁给药需求。 T4 噬菌体仅感染特定大肠杆菌,且无法侵染真核细胞 ...
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