相较于传统口服生物药，噬菌体递送系统具有独特优势。它能够 直接在肠道局部释放蛋白 ，避免系统性分布导致的脱靶效应。噬菌体与宿主菌形成动态平衡，可按需释放蛋白，减少频繁给药需求。 T4 噬菌体仅感染特定大肠杆菌，且无法侵染真核细胞 ...

Incubate the reaction at 15–25 °C for 15 min. 8| Add 1 μl of a dNTP solution (each at 10 mM) and 2 μl (5 units) of bacteriophage T4 DNA polymerase. Incubate the reaction mixture at 15–25 ...

Objective The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota ...

Crude oil and soil samples from crude oil contaminated sites were collected from Indian Oil Corporation Limited (IOCL), Chennai, India. For the isolation of crude oil degrading bacteria, 1 g of soil ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. The sewage water samples for phage isolation were collected in ...

Here, we report proof-of-concept studies for the development of next-generation influenza vaccines using the bacteriophage T4 virus-like particle (VLP) platform. Using the extracellular domain of ...

Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth, constituting a virtually unlimited resource to explore the development of biomedical therapies. The therapeutic ...