Histone modifications were analysed by chromatin immunoprecipitation (ChIP)-PCR. Conclusion Our findings suggest that IL-12-mediated co-activation of STAT1 and STAT4 alters histone modification, ...

A new LNP-mRNA vaccine significantly boosts immune response and enhances BCG protection against tuberculosis, offering a ...

Fish oil supplementation altered the profile of defense cells, which switched from a pro-inflammatory to an anti-inflammatory state, reversing a condition similar to type 2 diabetes.

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

GMP Human FGF-8b Protein (Cat. No. GMP-FGBH16) and Human FGF-8b Protein, Premium Grade (Cat. No. FGB-H5115) exhibit similar ...

Here, by leveraging scRNA-seq analysis, the authors reveal the role of naive CD4 T cell heterogeneity in disease states and therapeutic outcomes by characterizing a Th1-poised naive CD4 T cell ...

目前，MS 的发病机制仍是医学界亟待解开的谜题。已知它涉及针对髓鞘抗原的自身免疫反应，其中辅助性 T 细胞 4（CD4 + T 细胞），尤其是 Th1 和 Th17 亚群，在推动疾病进展中 “扮演” 着重要角色。然而，细胞毒性 T 细胞 8（CD8 + T 细胞）在 MS 和实验性自身免疫性脑脊髓炎（Experimental Autoimmune ...

With over half the cells in the human body being bacterial rather than human, and over 99% of the genes in the human body ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Here, by leveraging scRNA-seq analysis, the authors reveal the role of naive CD4 T cell heterogeneity in disease states and therapeutic outcomes by characterizing a Th1-poised naive CD4 T cell ...

Feb. 26, 2025 — Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice ...

Although in the post-Covid-19 era, pertussis incidences soared spectacularly, pertussis cases were already on the rise before ...