A major part of the drug development process is to weed out those compounds whose side effects overwhelm their therapeutic effects. This gets to the fundamental issue of efficacy vs effectiveness.

These drugs are useful, but they are also toxic, and the window for dosing to induce the desired therapeutic effect before causing toxicity is very narrow. The major toxicity related to ...

Scientists are designing a new type of drug that mimics the physiological benefits of breathing in thin 'mountain air'.

Panelists discuss how the Bayesian network meta-analysis showed which Janus kinase (JAK) inhibitors were most effective in ...

Gladstone researchers create a drug that replicates the cellular effects of low-oxygen therapy to treat inherited ...

Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to ...

A new study reveals that entacapone, a drug used to treat Parkinson’s disease, significantly disrupts the gut microbiome by ...

Peptide therapy enhances targeted medicine, utilizing specific peptides for effective treatment of cancer, metabolic disorders, and neurodegenerative diseases.

Ideally, for any drug, all of the unwanted effects would be in the former category and all of the therapeutic effects would be in the latter category. There are many examples of side effects of ...