The thyroid gland uses TPO along with iodine to generate the thyroid hormones triiodothyronine (T3) and thyroxine (T4). Together, these hormones regulate body temperature, heart rate, and metabolism.
Three principal thyroid autoantigens are involved in AITD. These are thyroperoxidase (TPO), thyroglobulin (Tg) and the TSH receptor. Other autoantigens, such as the Sodium Iodide Symporter (NIS ...