New research has detailed how UNC45, a protein chaperone, distinguishes between healthy and faulty myosin in muscle cells, ...

TYK Medicines Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently bonded to an EGFR (mutant)-targeting moiety through a ...

Scientists at Inventisbio Co. Ltd. and Inventisbio LLC have divulged E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.

This valuable study reports the first characterization of the CG14545 gene in Drosophila melanogaster, which the authors name "Sakura." Acting during germline stem cell fate and differentiation, ...

2004: Aaron Ciechanover, Avram Hershko and Irwin Rose jointly receive the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation ... Jumper (USA): ‘For protein structure ...

Herpes simplex virus (HSV), the viral agent causing human genital herpes, recurs easily and poses significant harm to patients, while also being associated with atherosc ...