Defects in ubiquitin–UBD interactions are relevant for development of disease, such as inflammation and cancer. The new structure-based insights provide strategies for the design of new ...

Figure 1: Domain structure of ubiquitin-specific proteases. DUB activities fall into three major functional categories (Fig. 3). First, ubiquitin can be transcribed from several genes as a linear ...

Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...

Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. Based on their functional domains and ...

Such interplay is seen with ADP-ribosylation and ubiquitylation. For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a ...

2004; Jundt et al., 2004). Such data introduce a new ubiquitin ligase, favorable for MM treatment. Ubiquitin-like protein Neural-precursor-cell-expressed-developmentally-down-regulated-8 (NEDD8) has a ...

Pharmaceutical scientists at the National University of Singapore (NUS) have developed a novel chemical reaction that enables ...

Department of Cell and Chemical Biology, Leiden University Medical Centre, 2333 ZCCLeiden, The Netherlands ...

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E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...