Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

This study presents an important discovery regarding the diversity and evolution of gall-forming microbial effectors. Supported by convincing computational structural predictions and analyses, the ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → RNA → ...

LC3/GABARAP is a family of ubiquitin-like proteins that mediate protein–protein interactions at every step of the autophagy pathway. Genetic knockdowns and knockouts of LC3/GABARAP proteins inhibit ...

Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, United States Neurodegenerative diseases are characterized by the progressive breakdown of neuronal ...

When my co-founder and I started Invoice Home, we wanted to build a business that could grow over time. We noted many inefficiencies while discussing our past experiences working within ...