New research has detailed how UNC45, a protein chaperone, distinguishes between healthy and faulty myosin in muscle cells, ...

Scientists at Inventisbio Co. Ltd. and Inventisbio LLC have divulged E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.

TYK Medicines Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently bonded to an EGFR (mutant)-targeting moiety through a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ubiquitin-conjugating enzymes (E2) play a ...

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States Center for Advanced Biotechnology and ...

Cells destroy any proteins that do not mature properly, as well as those that become damaged or are simply no longer needed. A small protein called ubiquitin helps to mark such unwanted proteins for ...

These ubiquitin chains serve as markers that target these toxic proteins for destruction ... Dambacher, Worden, Herzik et al. used electron microscopy to solve the structure of the lid complex in high ...