在这项研究中，研究人员根据ECM降解能力对巨噬细胞异质性进行了分类。一方面，提出了细胞外周的应力纤维参与细胞内溶酶体降解的ECM蛋白运输的证据。另一方面，VIM的破坏导致分散的内部足体组织并损害ECM降解，这是CD11b介导的过程。进一步描述了培养的 ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice. The ...

研究人员还观察到细胞会变得更具侵袭性，而且干细胞标志物也会被诱导，这或许就能为开发治疗人类乳腺癌和其它癌症的新型治疗方法开辟一扇大门。综上，本文研究结果表明，通过RNA干扰技术来靶向作用波形蛋白或XIST或能作为一种很有前景的乳腺癌新型疗法策略。（ ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, blood vessels, and lymphatic tissue (mesenchymal cells). Despite being widely ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...

Additionally, CRISPR/Cas gene editing was applied to healthy stem cells to study the roles of GFAP and vimentin. The absence of both proteins impaired organoid development, particularly in the cortex.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ...

However, regional variations in astrocyte distribution and morphology remain to be assessed comprehensively. This was the overarching objective of this postmortem study, which mainly exploited the ...

The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in human endothelial cells, binds to SARS-CoV-2-spike, and expedites SARS-CoV-2 ...