There are multiple CD4/CD6 inhibitors that are currently available for metastatic estrogen receptor-positive breast cancers, including Ibrance, Kisqali, and Verzenio. When you hear estrogen ...

CD4+ T cells play a central role in orchestrating immune responses and in maintaining a balance between pro- and anti- inflammatory responses. This tight balance between regulatory and effector ...

A team of researchers at the George R. Brown School of Engineering and Computing at Rice University has developed an innovative artificial intelligence (AI)-enabled, low-cost device that will make ...

Objectives To study the biology of the conventional T cells in human enthesis. Methods CD4+ and CD8+ T cells were investigated in 25 enthesis samples using immunofluorescence, cytometrically, bulk ...

Conventional therapies often fail to completely eradicate DCCs in patients. Herein, we demonstrate that intratumoral priming of antitumor CD4+ T helper 1 (Th1) cells was able to eliminate DCC burden ...

Background: In people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of ...

为探究儿童肥胖相关哮喘发病机制，美国阿尔伯特?爱因斯坦医学院研究人员开展单细胞转录组研究，发现多种 CD4 + T 细胞亚群与疾病相关，为治疗提供新思路。 儿童哮喘是一种常见的慢性疾病，严重影响孩子们的生活质量。哮喘的发病机制复杂多样，其中肥胖 ...

为解决 IBD 患者 VTE 发病机制不明的问题，爱尔兰皇家外科医学院的研究人员开展组织因子相关研究。结果发现 CD4+TF+ T 细胞及活化 PC 的调节作用。这为理解 IBD 与 VTE 关系及开发新疗法提供依据，强烈推荐科研读者阅读。

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...