They offer a holistic view on β-catenin and a state-of the art update on targeting Wnt-components for cancer therapy from leading experts in these fields. Celebrating its own 30th anniversary in 2012, ...

Perturbation experiments in GC tumour cell lines and xenograft models further demonstrated that HNF4α is downregulated by AMPKα signalling and the AMPK agonist metformin; blockade of HNF4α activity ...

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to ...

Hypothesis: Atrial myopathy due to the LMNA-S143P mutation, creates an arrhythmogenic substrate for AF by causing ion channel and chromatin remodeling. Approach: We performed clinical phenotyping and ...

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells ...

This is frequently diagnosed in dogs that were never spayed and the only type of cancer in dogs that has research showing ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to attach themselves to exosomes ...