Runx3 knockdown in murine AML cells efficiently impeded AML progress. Furthermore, we proved that RUNX3 bound and upregulated the expression of genes involved in DNA repair and antiapoptosis pathways ...

Sovateltide induces ET-B receptor-mediated signaling to produce significant anti-oxidative activity, antiapoptosis, mitochondrial fusion and biogenesis, angiogenesis, tissue re-perfusion, neuronal ...

Cancer is a major cause of human death all over the world. Traditional cancer treatments include surgery, radiotherapy, chemotherapy, immunotherapy, and hormone therapy. Although these conventional ...

This potentially important paper reports on interactions between L1TD1, an RNA binding protein (RBP), and the ancestral LINE-1 retrotransposon from which it originates. Overall, the results support a ...

These beneficial effects of melatonin could be explained partly by regulating antiapoptosis through SESN2- AMPK-mTOR. The results described herein help us understand the beneficial effects of ...

Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and radiation effect their responses. Resistance to apoptosis, therefore ...

This important paper reports functional interactions between L1TD1, an RNA binding protein (RBP), and its ancestral LINE-1 retrotransposon which is not modulated at the translational level. The ...

School of Life Science, South China Normal University, Guangzhou 510631, China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal ...

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan ...

Objectives This study aimed to investigate the relationship between serum regenerating protein Iα (REG Iα) levels and estimated glomerular filtration rate (eGFR) and to evaluate the diagnostic ...