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破解 HDACi 治疗癌症耐药困境:巨噬细胞与 CD47 的关键密码
HDACi 治疗对髓系恶性肿瘤中 CD47 表达的影响 研究人员还分析了公开的临床试验数据集,该数据集来自使用 entinostat 联合 5 - azacytidine 治疗血液系统恶性肿瘤的患者。结果发现,治疗后患者 CD34<sup>+</sup>细胞中 CD47 的表达显著升高。这说明,HDAC 抑制也可能增强恶性 ...
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