Now, a catalytically relevant X-ray crystal structure of an N–N-bond-forming enzyme, PipS, is reported and detailed insights into its catalytic mechanism are provided. Medium- and branched-chain ...

Brian's research focuses intersections between circadian rhythm and cancer. He utilizes cell line and mouse models of MYC-driven lung cancer to focus on how amplified MYC and metabolic stress disrupt ...

The possibilities for material design and production of plastic components are being expanded through 3D printing technology. However, there is a shortage of recyclable polymers that meet the ...

Lycia Therapeutics Inc. has reported progress in its immunology pipeline that comprises lysosomal targeting chimera (LYTAC)-based protein degradation therapies. The company is advancing its two lead ...

LCA-0321 is a LYTAC degrader designed to specifically bind and rapidly deplete anti-TSHR autoantibodies, the underlying cause of Graves’ disease and its extrathyroidal manifestations, including ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, Maharashtra 411008, India ...

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China ...

Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events ...