Broadly, these enzymes fall into 5 categories based on substrate specificity: (1) interstitial collagenases (MMP-1, -8, -13); (2) gelatinases (MMP-2,-9) and fibroblast activation protein ...

Chronic kidney disease (CKD) is a global public health issue characterized by progressive loss of kidney function, of which end-stage kidney disease (ESKD) is the last stage. The global increase in ...

Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and deep-tissue ...

Background The Ehlers-Danlos syndromes (EDS) are heritable disorders of connective tissue (HDCT), reclassified in the 2017 nosology into 13 subtypes. The genetic basis for hypermobile Ehlers-Danlos ...

Correspondence to: Dr P T G Elkington Department of Infectious Diseases, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; p.elkington{at}imperial.ac.uk Matrix ...

Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and ...

Objectives To determine whether the process of ubiquitination and/or activity of the 26S proteasome are involved in the induction of osteoarthritis (OA). Methods Bovine cartilage resorption assays, ...

Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI), Albert-Einstein-Straße 9, 07745 ...

5 Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK Correspondence to Dr Tom Wilkinson, Clinical and Experimental ...