Inside each cell, enzymes called cyclin-dependent kinases (CDKs) bind to cyclins to form complexes that drive mitosis. The CDK2–cyclin A2 complex regulates DNA replication, and the CDK1–cyclin ...

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

图 1. CSCO 乳腺癌诊疗指南（2024 版）CDK4/6 抑制剂如今已成为激素受体阳性晚期乳腺癌标准一线治疗方案。随着其大幅降价进入医保，这几年临床越来越多的乳腺癌患者开始使用 CDK4/6 抑制剂。以中性粒细胞减少为主的骨髓抑制是 ...

Monte Rosa Therapeutics (GLUE) announced the company will present preclinical data on the potential of its highly selective cyclin-dependent ...

Researchers have developed an innovative approach to treat cancers driven by kinase mutations, specifically targeting B cell ...

When this protein - cyclin-dependent kinase (CDK) - was suppressed, the treatment also prevented a change in the colour of their fur. This leaves the door open for scientists to help delay the ...

Ensem Therapeutics, Inc. (ENSEM), a pioneering drug discovery and development company that leverages its unique Kinetic ...

That deal included a $50 million upfront payment. CDK inhibitors, which treat cancer by blocking overactive cyclin-dependent kinases, are big business in breast cancer. Earlier this month an ...