Our work showed that CDK5 is activated by cyclin B1 and is required for proper cell division in non-neuronal cells. Indeed, like CDK1, CDK5 is also a canonical cell-division-cycle CDK. We have ...

Since, the discovery in the seventies and eighties of the core machinery regulating the eukaroytic cell cycle, the cyclin-dependent kinases (cdks) and cyclins, the cell-cycle field has grown ...

Poster presentation details are below: Author: Molina et al Title: CID-078, a first-in-class oral cyclin A/B-RxL inhibitor ... alterations that cause cell cycle dysregulation.