These amazing advances in cytoskeletal biophysics are the focus of the book, Mechanics of Motor Proteins and the Cytoskeleton by Jonathan (Joe) Howard, who is a leading expert in this field.
Similarly to mice that lack other regulators of the cytoskeleton, HEM1-deficient T cells showed decreased activation and proliferation compared with wild-type T cells. Surprisingly, some T-cell ...
We aim to understand the molecular logic behind the dynamics of the actin cytoskeleton at endocytic sites and how disturbances in this process affect physiology and disease progression. Leonardo is ...
We recently discovered that these structures are essential for the establishment of reticular adhesions. In our lab, we aim to elucidate the interplay of clathrin structures with the actin ...
The discovery opens the door to healthier aging in humans. The cytoskeleton provides most cells with their shape, structure, and internal organization. In turn, the cytoskeleton relies on a type ...
Researcher are now able to rebuild the switch that remodel the cytoskeleton. Images of an anaphase cytoskeleton in a dividing cell (left) and when rebuilt in vitro (right). PRC1 (green ...
Rho GTPases are molecular switches that control the cytoskeleton. The spreading of cancer cells from one part of the body to another, called metastasis, is one of the main causes of cancer death. To ...
Rac proteins help build a cell's scaffolding, called the cytoskeleton. The cytoskeleton is made of dynamic filaments that allow cells to maintain their shape or deform, as needed. In 1996, while ...