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揭秘糖尿病认知 “困境”:SGK1 如何搅乱海马体,又该如何破局?
同时,他们还给 db/db 小鼠用了一种叫 clemastine(一种被认为有促进髓鞘再生作用的药物)的药物,看看髓鞘再生能不能改善 DACD。结果发现,注射 AAV 后,db/db + shSgk1 组小鼠海马体中 SGK1 的表达明显降低,而且这些小鼠在行为学测试中的表现变好了,就好像 “变 ...
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