The challenges of translating neuroprotective interventions with promising efficacy in animal studies into effective ...

Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary ...

Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons ...

Evidence for chemotherapy-induced cognitive changes comes from studies that have used neuropsychological testing, imaging (structural and functional magnetic resonance imaging (MRI) and positron ...

Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile ...

Nerinetide is a synthetic eicosapeptide that interacts with post-synaptic density protein (PSD-95), disrupting the interactions between N-methyl-D-aspartate glutamate receptors and excitotoxic ...